Neuronale Zeroidlipofuszinose 8 (NCL-8) - Saluki ISAG also known as cerebellar hypoplasia

also known as cerebellar hypoplasia is an inherited neurological disease in dogs

Affected dogs often have to be on a strict low-fat diet to retain normal neurological function

Das Gehirn zeigt eine schwere Degeneration und Nekrose von Neuronen

Eine Form der progressiven Degeneration von Stäbchen und Zapfen ist die Photorezeptordegeneration bei Hunden und tritt in unterschiedlichen Altersstufen auf

Mutation: LAMP3 gene

Neuronale Zeroidlipofuszinose 8 (NCL-8) - Saluki ISAG also known as cerebellar hypoplasiaNeuronal ceroid lipofuscinosis (NCLs) are a group of hereditary diseases, characterized by progressive neuronal degeneration and the accumulation of autofluorescent cytoplasmic inclusions in the brain, retina, and other tissues. Clinical symptoms and progress of the disease include increased rates of irritability, with the possibility of outbursts of aggression, hallucinations, hyperactivity and seizures. Most animals lose their ability to coordinate